Updated: Mar 8, 2020
With the increase in computing power I'm wondering how much of (organic) computational chemistry could be done on a single PC.
A short test run on an older Dell Optiplex 9010 All-In-One with an Intel i5-3470s (all core turbo about 3200 MHz) and 8GB of DDR3L RAM @ 1600 MHz showed that it should be possible, at least on newer machines, to run small projects.
Even a DLPNO-CCSD(T) single point calculations of Adenine with the cc-pVTZ basis using ORCA 4.1 took only 41 minutes.
Timings for individual modules:
Sum of individual times ... 2485.404 sec (= 41.423 min)
GTO integral calculation ... 0.997 sec (= 0.017 min) 0.0 %
SCF iterations ... 46.103 sec (= 0.768 min) 1.9 %
MDCI module ... 2438.304 sec (= 40.638 min) 98.1 %
****ORCA TERMINATED NORMALLY****
TOTAL RUN TIME: 0 days 0 hours 41 minutes 26 seconds 12 msec