Dennis Svatunek
Personal Research Website


Peer-Reviewed Publications
2021
32.
D. Svatunek, M. Wilkovitsch, L. Hartmann, K.N. Houk, H. Mikula
ChemRxiv preprint, DOI: 10.33774/chemrxiv-2021-vnwzk
33.
A. Turlik, K.N. Houk, D. Svatunek
Origin of Increased Reactivity in Rhenium-Mediated Cycloadditions of Tetrazines
Journal of Organic Chemistry (accepted), 2021
32.
32.
R. Garcia-Vazquez, U.M. Battisti, J.T. Jørgensen, V. Shalgunov, L. Hvass, D.L. Stares, I. Nymann Petersen, F. Crestey, A. Löffler, D. Svatunek, J.L. Kristensen, H. Mikula, A. Kjaer, M. Herth
Direct Aromatic 18F-Labeling of Highly Reactive Tetrazines for Pretargeted Bioorthogonal PET Imaging
Chemical Science, 2021, DOI: 10.1039/D1SC02789A
31.
M. Ramirez, D. Svatunek, F. Liu, N.K. Garg, K.N. Houk
Origins of Endo Selectivity in Diels–Alder Reactions of Cyclic Allene Dienophiles
Angewandte Chemie International Edition (accepted), 2021, DOI: 10.1002/anie.202101809
30.
L. De Pascalis, M. Yau, D. Svatunek, Z. Tan, S. Tekkam, K.N. Houk, M.G. Finn
The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation
Organic Letters, 2021, 23, 3751-3754
29.
P. Chen, P. Ma, X. He, D. Svatunek, F Liu, K.N. Houk
Computational Exploration of Ambiphilic Reactivity of Azides and Sustmann’s Paradigmatic Parabola
The Journal of Organic Chemistry, 2021, 86, 5792-5804
28.
J. Stéen, J.T. Jørgensen, C. Denk, U.M. Battisti, K. Nørregaard, P. Edem, K. Bratteby, V. Shalgunov, M. Wilkovitsch, D. Svatunek, C.B.M. Poulie, L. Hvass L, S Marina, T. Wanek, R. Rossin, M. Robillard, J.L. Kristensen, H. Mikula, A. Kjaer, M. Herth
Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted in Vivo Chemistry
ACS Pharmacology & Translational Science, 2021, 4, 824-833
27.
D.Svatunek, T. Hansen, K.N. Houk, T.A. Hamlin
How the Lewis Base F– Catalyzes the 1,3-Dipolar Cycloaddition between Carbon Dioxide and Nitrilimines
The Journal of Organic Chemistry, 2021, 86, 4320-4325
2020
26.
I. Saha, E.K. Dang, D. Svatunek, K.N. Houk, P.G. Harran
Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 24679-24690
25.
K. Johann, D. Svatunek, C. Seidl, S. Rizzelli, T. Bauer, L. Braun, K. Koynov, H. Mikula, M. Barz
Tetrazine- and trans-Cyclooctene-functionalised Polypept(o)ides for Fast Bioorthogonal Tetrazine Ligation
Polymer Chemistry, 2020, 11, 4396-4407
24.
V.B. Delchev, E. Horkel, D. Svatunek
Excited-state photocycodimerization of 6-azauracil to oxazetidine cyclodimer: A mechanism elucidation in water surroundings
Journal of Molecular Structure, 2020, 1205, 127571
23.
D. Svatunek, R.P. Pemberton, J.L. Mackay, P. Liu, K.N. Houk
The Journal of Organic Chemistry, 2020, 85, 3858-3864
22.
D. Svatunek, G. Eilenberger, C. Denk, D. Lumpi, C. Hametner, G. Allmaier, H. Mikula
Live Monitoring of Strain‐Promoted Azide Alkyne Cycloadditions in Complex Reaction Environments by Inline ATR‐IR Spectroscopy
Chemistry – A European Journal, 2020, 26, 9851-9854
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Part of the "Hot Topic: Click Chemistry" series
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Part of the "Young Chemists 2020" special selection
21.
J. Tu, D. Svatunek, S. Parvez, H.J. Eckvahl, M. Xu, R. Peterson, K.N. Houk, R.M. Franzini
Isonitrile-responsive and Bioorthogonally Removable Tetrazine Protecting Groups
Chemical Science, 2020, 11, 169-179
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selected as Edge Article
20.
E.J.L. Stéen, J.T. Jørgensen, K. Johann, K. Nørregaard, B. Sohr, D. Svatunek, A. Birke, V. Shalgunov, P.E. Edem, R. Rossin, C. Seidl, F. Schmid, M.S. Robillard, J.L. Kristensen, H. Mikula, M. Barz, A. Kjær, M.M. Herth
Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging
ACS Nano, 2020, 14, 568-584
2019
19.
S. Kramer, D. Svatunek, I. Alberg, B. Gräfen, S. Schmitt, L. Braun, A.H.A.M. van Onzen, R. Rossin, K. Koynov, H. Mikula, R. Zentel
HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation
Biomacromolecules, 2019, 20, 3786-3797
18.
J. Weber, D. Svatunek, S. Krauter, G. Tegl, C. Hametner, P. Kosma, H. Mikula
2-O-Benzyloxycarbonyl protected glycosyl donors: a revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation
Chemical Communications, 2019, 55, 12543-12546
17.
D. Svatunek, K.N. Houk
autoDIAS: A Python Tool for an Automated Distortion/Interaction Activation Strain Analysis
Journal of Computational Chemistry, 2019, 40, 2509-2515
16.
J. Tu, D. Svatunek, S. Parvez, A.C. Liu, B.J. Levandowski, H.J. Eckvahl, R.T. Peterson, K.N. Houk, R.M. Franzini
Stable, Reactive and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles
Angewandte Chemie International Edition, 2019, 58, 9043-9048
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selected as Hot Paper
15.
B.J. Levandowski,‡ D. Svatunek,‡ B. Sohr, H. Mikula, K.N. Houk
Secondary Orbital Interactions Enhance the Reactivity of Alkynes in Diels-Alder Cycloadditions
Journal of the American Chemical Society, 2019, 141, 2224-2227
14.
D. Svatunek, N. Houszka, T.A. Hamlin, F.M. Bickelhaupt, H. Mikula
Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne‐Azide Cycloadditions
Chemistry – A European Journal, 2019, 25, 754-758
13.
top 10% most downloaded papers in European Journal of Organic Chemistry in the first 12 months after publication
T.A. Hamlin, D. Svatunek, S. Yu, L. Ridder, I. Infante, L. Visscher, F.M. Bickelhaupt
Elucidating the Trends in Reactivity of Aza‐1,3‐Dipolar Cycloadditions
European Journal of Organic Chemistry, 2019, 2-3, 378-386
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Top Downloaded Article
2018
12.
top 10% most downloaded papers in ChemistryOpen in the first 12 months after publication
S. Yu, H.M. de Bruijn, D. Svatunek, T.A. Hamlin, F.M. Bickelhaupt
Factors Controlling the Diels–Alder Reactivity of Hetero‐1,3‐Butadienes
ChemistryOpen, 2018, 7, 995-1004
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Top Downloaded Article
11.
D. Svatunek, C. Denk, H. Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
Monatshefte für Chemie – Chemical Monthly, 2018, 149, 833
10.
E.P. Yankov, R.I. Bakalska, E. Horkel, D. Svatunek, V.B. Delchev
Experimental and theoretical study of the excited-state tautomerism of 6-azauracil in water surroundings
Chemical Physics, 2018, 515, 663-671
9.
S. Kronister, D. Svatunek, C. Denk, H. Mikula
Acylation-Mediated ‘Kinetic Turn-On’ of 3-Amino-1,2,4,5-tetrazines
Synlett, 2018, 29, 1297-1302
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Thieme News article: "Increasing Tetrazine Reactivity in the IEDDA Reaction"
2017
8.
C. Denk, M. Wilkovitsch, P. Skrinjar, D. Svatunek, S. Mairinger, C. Kuntner, T. Filip, J. Fröhlich, T. Wanek, H. Mikula
[18F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry
Organic and Biomolecular Chemistry, 2017, 15, 5976-5982
2016
7.
M. Wang, D. Svatunek, K. Rohlfing, Y. Liu, H. Wang, B. Giglio, H. Yuan, Z. Wu, Z. Li, J. Fox
Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of 18F-PET Probes via Tetrazine Ligation
Theranostics, 2016, 6, 887-895
6.
D. Svatunek, C. Denk, V. Rosecker, B. Sohr, C. Hametner, G. Allmaier, J. Fröhlich, H. Mikula
Efficient low-cost preparation of trans-cyclooctenes using a simplified flow setup for photoisomerization
Monatshefte für Chemie – Chemical Monthly, 2016, 147, 579–585
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Young Scientists Best Paper Award - Springer/Nature
5.
C. Denk, D. Svatunek, S. Mairinger, J. Stanek, T. Filip, D. Matscheko, J. Fröhlich, C. Kuntner, T. Wanek, H. Mikula
Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry
Bioconjugate Chemistry, 2016, 27, 1707-1712
2014
4.
C. Denk, D. Svatunek, T. Filip, T. Wanek, D. Lumpi, J. Fröhlich, C. Kuntner, H. Mikula
Development of a 18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging
Angewandte Chemie International Edition, 2014, 53, 9655-9659
3.
H. Mikula, D. Svatunek, P. Skrinjar, E. Horkel, C. Hametner, J. Fröhlich
DFT study of the Lewis acid mediated synthesis of 3-acyltetramic acids
Journal of Molecular Modeling, 2014, 20, 2181
2.
H. Mikula, J. Weber, D. Svatunek, P. Skrinjar, G. Adam, R. Krska, C. Hametner, J. Fröhlich
Synthesis of Zearalenone-16-β,D-Glucoside and Zearalenone-16-Sulfate: A Tale of Protecting Resorcylic Acid Lactones for Regiocontrolled Conjugation
Beilstein Journal of Organic Chemistry, 2014, 10, 1129-1134
2013
1.
H. Mikula, D. Svatunek, D. Lumpi, F. Glöcklhofer, C. Hametner, J. Fröhlich
Practical and Efficient Large-Scale Preparation of Dimethyldioxirane
Organic Process Research & Development, 2013, 17, 313-316