Cover Gallery

Peer-Reviewed Publications

2021

32.

R. Garcia-Vazquez, U.M. Battisti, J.T. Jørgensen, V. Shalgunov, L. Hvass, D.L. Stares, I. Nymann Petersen, F. Crestey, A. Löffler, D. Svatunek, J.L. Kristensen, H. Mikula, A. Kjaer, M. Herth

Direct Aromatic 18F-Labeling of Highly Reactive Tetrazines for Pretargeted Bioorthogonal PET Imaging

ChemRxiv preprint, DOI: 10.26434/chemrxiv.14068712.v1 

31.

M. Ramirez, D. Svatunek, F. Liu, N.K. Garg, K.N. Houk

Origins of Endo Selectivity in Diels–Alder Reactions of Cyclic Allene Dienophiles

Angewandte Chemie International Edition (accepted), 2021, DOI: 10.1002/anie.202101809

30.

L. De Pascalis, M. Yau, D. Svatunek, Z. Tan, S. Tekkam, K.N. Houk, M.G. Finn 

The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation

Organic Letters (accepted), 2021, DOI: 10.1021/acs.orglett.1c01164

29.

P. Chen, P. Ma, X. He, D. Svatunek, F Liu, K.N. Houk

Computational Exploration of Ambiphilic Reactivity of Azides and Sustmann’s Paradigmatic Parabola

The Journal of Organic Chemistry, 2021, DOI: 10.1021/acs.joc.1c00239

28.

J. Stéen, J.T. Jørgensen, C. Denk, U.M. Battisti, K. Nørregaard, P. Edem, K. Bratteby, V. Shalgunov, M. Wilkovitsch, D. Svatunek, C.B.M. Poulie, L. Hvass L, S Marina, T. Wanek, R. Rossin, M. Robillard, J.L. Kristensen, H. Mikula, A. Kjaer, M. Herth
Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted in Vivo Chemistry

ACS Pharmacology & Translational Science, 2021, DOI: 10.1021/acsptsci.1c00007

27.

D.Svatunek, T. Hansen, K.N. Houk, T.A. Hamlin
How the Lewis Base F– Catalyzes the 1,3-Dipolar Cycloaddition between Carbon Dioxide and Nitrilimines
The Journal of Organic Chemistry, 2021, DOI: 10.1021/acs.joc.0c02963

2020

26.

I. Saha, E.K. Dang, D. Svatunek, K.N. Houk, P.G. Harran
Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles
Proceedings of the National Academy of Sciences of the United States of America, 2020, DOI: 10.1073/pnas.2007304117

25.

K. Johann, D. Svatunek, C. Seidl, S. Rizzelli, T. Bauer, L. Braun, K. Koynov, H. Mikula, M. Barz
Tetrazine- and trans-Cyclooctene-functionalised Polypept(o)ides for Fast Bioorthogonal Tetrazine Ligation
Polymer Chemistry, 2020, DOI: 10.1039/D0PY00375A

24.

V.B. Delchev, E. Horkel, D. Svatunek
Excited-state photocycodimerization of 6-azauracil to oxazetidine cyclodimer: A mechanism elucidation in water surroundings
Journal of Molecular Structure, 2020, 1205, 127571

23.

D. Svatunek, R.P. Pemberton, J.L. Mackay, P. Liu, K.N. Houk 

Concerted [4+2] and Stepwise (2+2) Cycloadditions of Tetrafluoroethylene with Butadiene: DFT and DLPNO-UCCSD(T) Explorations

The Journal of Organic Chemistry, 2020, 85, 3858-3864

22.

D. Svatunek, G. Eilenberger, C. Denk, D. Lumpi, C. Hametner, G. Allmaier, H. Mikula 
Live Monitoring of Strain‐Promoted Azide Alkyne Cycloadditions in Complex Reaction Environments by Inline ATR‐IR Spectroscopy

Chemistry – A European Journal, 2020, DOI: 10.1002/chem.201905478

21.

J. Tu, D. Svatunek, S. Parvez, H.J. Eckvahl, M. Xu, R. Peterson, K.N. Houk, R.M. Franzini 
Isonitrile-responsive and Bioorthogonally Removable Tetrazine Protecting Groups
Chemical Science, 2020, 11, 169-179

  • selected as Edge Article

20.

E.J.L. Stéen, J.T. Jørgensen, K. Johann, K. Nørregaard, B. Sohr, D. Svatunek, A. Birke, V. Shalgunov, P.E. Edem, R. Rossin, C. Seidl, F. Schmid, M.S. Robillard, J.L. Kristensen, H. Mikula, M. Barz, A. Kjær, M.M. Herth
Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging
ACS Nano, 2020, 14, 568-584

2019

19.

S. Kramer, D. Svatunek, I. Alberg, B. Gräfen, S. Schmitt, L. Braun, A.H.A.M. van Onzen, R. Rossin, K. Koynov, H. Mikula, R. Zentel
HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation
Biomacromolecules, 2019, DOI: 10.1021/acs.biomac.9b00868

18.

J. Weber, D. Svatunek, S. Krauter, G. Tegl, C. Hametner, P. Kosma, H. Mikula
2-O-Benzyloxycarbonyl protected glycosyl donors: a revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation
Chemical Communications, 2019, 55, 12543-12546

17.

D. Svatunek, K.N. Houk
autoDIAS: A Python Tool for an Automated Distortion/Interaction Activation Strain Analysis

Journal of Computational Chemistry, 2019, 40, 2509-2515

16.

J. Tu, D. Svatunek, S. Parvez, A.C. Liu, B.J. Levandowski, H.J. Eckvahl, R.T. Peterson, K.N. Houk, R.M. Franzini
Stable, Reactive and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles
Angewandte Chemie International Edition, 2019, 58, 9043-9048

15.

B.J. Levandowski,‡ D. Svatunek,‡ B. Sohr, H. Mikula, K.N. Houk
Secondary Orbital Interactions Enhance the Reactivity of Alkynes in Diels-Alder Cycloadditions

Journal of the American Chemical Society, 2019, 141, 2224-2227

14.

D. Svatunek, N. Houszka, T.A. Hamlin, F.M. Bickelhaupt, H. Mikula
Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne‐Azide Cycloadditions

Chemistry – A European Journal, 2019, 25, 754-758

13.

T.A. Hamlin, D. Svatunek, S. Yu, L. Ridder, I. Infante, L. Visscher, F.M. Bickelhaupt
Elucidating the Trends in Reactivity of Aza‐1,3‐Dipolar Cycloadditions

European Journal of Organic Chemistry, 2019, 2-3, 378-386

  • Top Downloaded Article

2018

12.

S. Yu, H.M. de Bruijn, D. Svatunek, T.A. Hamlin, F.M. Bickelhaupt
Factors Controlling the Diels–Alder Reactivity of Hetero‐1,3‐Butadienes

ChemistryOpen, 2018, 7, 995-1004

  • Top Downloaded Article

11.

D. Svatunek, C. Denk, H. Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines

Monatshefte für Chemie – Chemical Monthly, 2018, 149, 833

10.

E.P. Yankov, R.I. Bakalska, E. Horkel, D. Svatunek, V.B. Delchev
Experimental and theoretical study of the excited-state tautomerism of 6-azauracil in water surroundings
Chemical Physics, 2018, 515, 663-671

9.

S. Kronister, D. Svatunek, C. Denk, H. Mikula
Acylation-Mediated ‘Kinetic Turn-On’ of 3-Amino-1,2,4,5-tetrazines

Synlett, 2018, 29, 1297-1302

 

2017

8.

C. Denk, M. Wilkovitsch, P. Skrinjar, D. Svatunek, S. Mairinger, C. Kuntner, T. Filip, J. Fröhlich, T. Wanek, H. Mikula
[18F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry
Organic and Biomolecular Chemistry, 2017, 15, 5976-5982

2016

7.

M. Wang, D. Svatunek, K. Rohlfing, Y. Liu, H. Wang, B. Giglio, H. Yuan, Z. Wu, Z. Li, J. Fox
Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of 18F-PET Probes via Tetrazine Ligation
Theranostics, 2016, 6, 887-895

6.

D. Svatunek, C. Denk, V. Rosecker, B. Sohr, C. Hametner, G. Allmaier, J. Fröhlich, H. Mikula
Efficient low-cost preparation of trans-cyclooctenes using a simplified flow setup for photoisomerization
Monatshefte für Chemie – Chemical Monthly, 2016, 147, 579–585

  • Young Scientists Best Paper Award - Springer/Nature

5.

C. Denk, D. Svatunek, S. Mairinger, J. Stanek, T. Filip, D. Matscheko, J. Fröhlich, C. Kuntner, T. Wanek, H. Mikula
Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry
Bioconjugate Chemistry, 2016, 27, 1707-1712

2014

4.

C. Denk, D. Svatunek, T. Filip, T. Wanek, D. Lumpi, J. Fröhlich, C. Kuntner, H. Mikula
Development of a 18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging
Angewandte Chemie International Edition, 2014, 53, 9655-9659

3.

H. Mikula, D. Svatunek, P. Skrinjar, E. Horkel, C. Hametner, J. Fröhlich
DFT study of the Lewis acid mediated synthesis of 3-acyltetramic acids

Journal of Molecular Modeling, 2014, 20, 2181

2.

H. Mikula, J. Weber, D. Svatunek, P. Skrinjar, G. Adam, R. Krska, C. Hametner, J. Fröhlich
Synthesis of Zearalenone-16-β,D-Glucoside and Zearalenone-16-Sulfate: A Tale of Protecting Resorcylic Acid Lactones for Regiocontrolled Conjugation
Beilstein Journal of Organic Chemistry, 2014, 10, 1129-1134

2013

1.

H. Mikula, D. Svatunek, D. Lumpi, F. Glöcklhofer, C. Hametner, J. Fröhlich
Practical and Efficient Large-Scale Preparation of Dimethyldioxirane

Organic Process Research & Development, 2013, 17, 313-316

Dennis Svatunek

© 2018 – 2020

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