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New paper with the Boger group on 1,2,3-Triazine cycloadditions
Together with the Boger lab we recently published our work "Mechanistic Insights into the Reaction of Amidines with 1,2,3-Triazines and...

Dennis Svatunek
Jun 22, 20221 min read
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New JACS paper: Uncovering the Key Role of Distortion in Bioorthogonal Tetrazine Tools That Defy the
Our paper on the reactivity of 2-pyridyl tetrazines is now open access in JACS: https://pubs.acs.org/doi/10.1021/jacs.2c01056

Dennis Svatunek
May 19, 20221 min read
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Creating 2 Billion virtual compounds - new paper with the Harran group
Together with the Harran group (UCLA) we worked on a computational workflow to create a gigalibrary of composite peptidic macrocycles...

Dennis Svatunek
Sep 18, 20201 min read
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New paper in Polymer Chemistry: Tetrazine- and trans-cyclooctene-functionalised polypept(o)ides
In this paper we describe the synthesis of tetrazine and trans-cyclooctene modified polypept(o)ides and their bioorthogonal reactivity....

Dennis Svatunek
Jun 29, 20201 min read
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![New paper about the "Concerted [4+2] and Stepwise (2+2) Cycloadditions of Tetrafluoroethylene w](https://static.wixstatic.com/media/cc1c9a_ec1c3e2f3f30454896281f9df6799773~mv2.png/v1/fill/w_427,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/cc1c9a_ec1c3e2f3f30454896281f9df6799773~mv2.webp)
![New paper about the "Concerted [4+2] and Stepwise (2+2) Cycloadditions of Tetrafluoroethylene w](https://static.wixstatic.com/media/cc1c9a_ec1c3e2f3f30454896281f9df6799773~mv2.png/v1/fill/w_454,h_266,fp_0.50_0.50,q_95,enc_avif,quality_auto/cc1c9a_ec1c3e2f3f30454896281f9df6799773~mv2.webp)
New paper about the "Concerted [4+2] and Stepwise (2+2) Cycloadditions of Tetrafluoroethylene w
We published a mechanistic study of the 2+2 and 4+2 cycloadditions between tetrafluorotheylene and butadiene. Read it here! (open access)

Dennis Svatunek
Feb 14, 20201 min read
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New paper: Live Monitoring of Strain‐Promoted Azide Alkyne Cycloadditions in Complex Reaction Enviro
We describe how ATR-IR can be used to follow strain-promoted azide alkyne cycloadditions even in biological solvent. Read this open...

Dennis Svatunek
Jan 18, 20201 min read
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New ACS nano paper: Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of
We demonstrate that PeptoBrushes can be used for pretargeted nuclear imaging. These PeptoBrushes also show unusual bioorthogonal...

Dennis Svatunek
Dec 11, 20191 min read
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New article on new glycosyl donors for diastereoselective glycosylations published in Chemical Commu
This paper includes work I performed in my bachelor thesis. Great work by all authors! Link to paper (open access)

Dennis Svatunek
Sep 27, 20191 min read
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New article on tetrazine modified nanoparticles published in Biomacromolecules
Our paper together with the Zentel group at Johannes Gutenberg University Mainz is now available in Biomacromolecules. Great work by...

Dennis Svatunek
Sep 27, 20191 min read
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New paper: Isonitrile-responsive and Bioorthogonally Removable Tetrazine Protecting Groups
Together with the Franzini group we unraveled the mechanism of an accelerated release reaction in an isonitrile/tetrazine click to...

Dennis Svatunek
Sep 14, 20191 min read
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autoDIAS published in JCC
Our paper about our python tool for an automated Distortion/Interaction Activation Strain analysis is online in the Journal of...

Dennis Svatunek
Jul 8, 20191 min read
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Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonit
Our paper together with the Franzini group "Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with...

Dennis Svatunek
Jun 20, 20191 min read
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Cover Picture in Angewandte Chemie
Our article "Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles" is featured as a...

Dennis Svatunek
Jun 8, 20191 min read
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